METHYL GLYCINATE HYDROCHLORIDE
Glycine methyl ester hydrochloride
CAS: 5680-79-5
Molecular Formula: C3H8ClNO2
METHYL GLYCINATE HYDROCHLORIDE - Names and Identifiers
METHYL GLYCINATE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C3H8ClNO2 |
| Molar Mass | 125.55 |
| Density | 1.000 |
| Melting Point | 175°C (dec.)(lit.) |
| Boling Point | 82.1°C at 760 mmHg |
| Water Solubility | >1000 g/L (20 ºC) |
| Solubility | >1000 g/L (20°C) |
| Vapor Presure | 79.8mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| BRN | 3593644 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Hygroscopic |
| MDL | MFCD00012870 |
| Physical and Chemical Properties | This product is white crystal, m. P. 175 ℃ (decomposition), soluble in water, easy to absorb moisture. |
| Use | Used as raw materials for household insecticides, pyrethroids and pharmaceutical industry |
METHYL GLYCINATE HYDROCHLORIDE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29224995 |
METHYL GLYCINATE HYDROCHLORIDE - Upstream Downstream Industry
| Raw Materials | Sodium carbonate Methyl alcohol Glycine |
METHYL GLYCINATE HYDROCHLORIDE - Reference
| Reference Show more | Zhang Xingying, Lin Yameng, Qu Yuan, et al. Investigation of transdermal penetration enhancing activity of amino acid ester ionic liquids [J]. Chinese Journal of Pharmaceutical Industry, 2017, 29 (4). |
METHYL GLYCINATE HYDROCHLORIDE - Introduction
Soluble in water, solubility in water:>1000G/L(20 C); Slightly soluble in ethanol.
Last Update：2022-10-16 17:26:27
METHYL GLYCINATE HYDROCHLORIDE - Reference Information
| Use | glycine methyl ester hydrochloride is useful as a raw material for household insecticides, pyrethroids, and raw materials for the pharmaceutical industry. glycine methyl ester hydrochloride is an important intermediate in the preparation of chrysanthemum acid and dichloro-Chrysanthemum acid, and is also an intermediate of fungicide isourea. used as household insecticide, pyrethroid raw materials and pharmaceutical industry raw materials used in medicine, food, organic synthesis, etc. |
| production method | may be prepared using glycine or chloroacetic acid as a starting material. As described below. Glycine as raw material method with dry hydrogen chloride gas into anhydrous ethanol, first made into hydrogen chloride ethanol solution, and then add glycine, heating and stirring for esterification, the reaction temperature is controlled at 80~85 ℃, after glycine was completely dissolved, the mixture was stirred for several minutes, and the reaction solution was transferred to a crystallization pan while hot, cooled to crystallize, and filtered to obtain glycine ethyl ester hydrochloride. Reaction equation: NH2CH2COOH C2H5O[HCl]→ NH2CH2COOC2H5 · HCl can also be added with glycine and anhydrous ethanol in the reactor with stirring, heated to 60 ℃, hydrogen chloride gas, hydrogen chloride is passed to the end point when the reactant is completely dissolved and hydrogen chloride is continued to recrystallize. The reaction solution is transferred to the crystallization pan, and the crystallization is cooled while stirring, filtered, washed with absolute ethanol, the glycine ethyl ester hydrochloride was obtained by drying. Chloroacetic acid as raw material to chloroacetic acid, urotropine and anhydrous ethanol was added to the reactor, at 45 ℃ when human ammonia, pH = 8~8.5, control the rate of ammonia, in order to maintain the reaction temperature between 40 to 65 ° C., after the ammonia gas was passed, the reaction was maintained at 65 ° C. For 1H, and then the temperature was lowered to 30 ° C., and the hydrogen chloride-anhydrous ethanol solution was added dropwise. After the dropwise addition, react at 70 ℃ for 2H, and then filter at 62~65 ℃ while hot to separate ammonium chloride crystals. The filtrate is placed in a crystallization Pan, cooled to 10 ℃, and stirred, edge crystallization, Crystal filtration, drying to glycine ethyl ester hydrochloride. Reaction equation: ClCH2COOH NH3 [ethanol] → NH2CH2COOH[C2H5OH]→[HCl]NH2CH2COOH · HCl, methyl glycinate hydrochloride can be obtained by replacing ethanol with methanol. Reaction equation: NH2CH2COOH CH3OH[HCl]→ NH2CH2COOCH3 · HCl |
Last Update：2024-04-09 21:11:58
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View History
METHYL GLYCINATE HYDROCHLORIDE
2-(3-氰基氧杂环丁烷-3-基)乙酸乙酯
反-4-乙基环已醇
叔-丁基 3-(二氟甲基)-3-羟基吖丁啶-1-甲酸基酯
L-叔亮氨酸甲酯盐酸盐 (白色结晶粉末
1-溴-2-(三氟甲基)苯
phosphorofluoridate
N-[(9H-芴-9-基甲氧基)羰基]-L-谷氨酸 5-(1-甲基-1-苯基乙基)酯
ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE
2-(3-氰基氧杂环丁烷-3-基)乙酸乙酯
反-4-乙基环已醇
叔-丁基 3-(二氟甲基)-3-羟基吖丁啶-1-甲酸基酯
L-叔亮氨酸甲酯盐酸盐 (白色结晶粉末
1-溴-2-(三氟甲基)苯
phosphorofluoridate
N-[(9H-芴-9-基甲氧基)羰基]-L-谷氨酸 5-(1-甲基-1-苯基乙基)酯
ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE
Raw Materials for METHYL GLYCINATE HYDROCHLORIDE